The Substitute Madam Amazes the World Once More - Chapter 450 - Using Medicine to Treat The Problem

As monstrous invaders ravage the world, Ryzen Kael— a man shattered by a tragedy ten years ago— faces his final moments. But just as death closes in, a mysterious system awakens within him, offering a path beyond his limits.Now, with nothing left to lose, he steps into a dangerous journey of survival and power, defying fate and unlocking abilities beyond imagination. Follow his rise as he challenges destiny itself, carving his name into history!Author's other storiesThe Unrivaled Holder: Rise of the Dragon Monarch - 3rd Season Ongoing

The eldest daughter of the Yan family, Yan Jinyu, who has been missing for 16 years, has been found. She is brought back from an orphanage by her fiancé, the Second Master of the Yin family.

After Reincarnating into Naruto World at the Warring State Era as an Uzumaki, Masahiko thought that he got a useless System. He lived for 48 years as a normal, below average Uzumaki Shinobi.

That changed when he finally knew how the system works the day of his 49th Birthday!

- Description from Novelupdates

She is the eldest daughter of the Zanying family, born noble, beautiful and beautiful, with a peerless appearance;

In the last life, she gave everything she had to help him win the world, but in return she got all her family killed;

In the last life, the person who killed her ascended to the throne of the phoenix, the mother of the world, the honor and wealth, but she was imprisoned in the cold palace and suffered all kinds of humiliation;

Reborn in elementary school, she is no longer a pawn at the mercy of others, she is the best in the world in medical skills, and she has a delicate heart to plan and plan the world;

In this life, she wants to protect her dear ones, to avenge her revenge, and to avenge her grudges;

In this life, she wants that young man who rides his horse and sings lightly, regardless of sword, light or sword, to live a long and safe life!